Category: Lubrizol

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Lubrizol Life Science Health has launched Apisolex, a novel solubility-enhancing excipient for use in parenteral drug products.

This technology overcomes solubility hurdles that cannot be resolved by existing excipients or manufacturing techniques.

At present, 60-90% of potential new active pharmaceutical ingredients (APIs) in development pipelines, and more than 40% of those in reformulation, are poorly water soluble. As solubility impacts bioavailability and efficacy, tackling the growing number of poorly soluble APIs is critical to secure the route to market for promising therapeutics.

With the ability to improve solubility by up to 50,000-fold and support high drug loading, Apisolex technology provides access to new and improved parenteral drug products. This is especially relevant in the oncology field, as direct injection of drugs into the bloodstream ensures higher bioavailability and lower patient variability, compared to oral delivery.

Understanding the need of the industry, Apisolex polymer is designed to work with the simplest formulation techniques to streamline manufacturing and minimize API loss with high encapsulation rate. Comprised of biocompatible, biodegradable building blocks, Apisolex is a non-toxic, non-immunogenic alternative to PEG or surfactants.

“Apisolex is the first solubility-enhancing excipient for parenteral use introduced in more than 20 years,” says Rob Lee, President of the CDMO Division of LLS Health. “With its toxicity profile and simple processing techniques, Apisolex polymer can both improve existing drugs and enable some important new molecules.”

Apisolex excipient’s robust patent protection enables both the formulation of new chemical entities and the reformulation of existing APIs to enhance their therapeutic effect and deliver improved patient outcomes via the FDA’s 505(b)(2) regulatory pathway.

LLS Health already has a portfolio of differentiated excipients to help drug developers transform drug products which include the original Carbopol®, Pemulen™ TR-2 NF, and Noveon® AA-1 excipients. Solubility enhancing Apinovex™ polymer, used to maximize API concentration and stability in oral amorphous solid dispersion drug formulations, was introduced last year.

© 2022 David Mazor

Disclosure: David Mazor is a freelance writer focusing on Berkshire Hathaway. The author is long in Berkshire Hathaway, and this article is not a recommendation on whether to buy or sell a stock. The information contained in this article should not be construed as personalized or individualized investment advice. Past performance is no guarantee of future results.

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Today, data centers are largely cooled by inefficient and expensive air conditioners. Lubrizol’s immersion cooling ecosystem solution, using CompuZol™ Immersion fluids, addresses the limitations posed by air-cooled methods by delivering a turn-key, sustainable immersion-cooled solution that enables superior thermal management and increased infrastructure density. The solution helps protect customers’ enterprise infrastructure investments and provides greater assurance to future technologies than traditional air-cooled systems, all while helping customers reach their global sustainability goals.

Now, Berkshire Hathaway’s The Lubrizol Corporation and Park Place Technologies have announced that Park Place will become a certified partner of this ecosystem solution, leveraging its market-leading capabilities to provide on-demand service, maintenance and real-time monitoring capabilities to customers utilizing immersion-cooled solutions from Lubrizol. Park Place is an Intel^® Data Center Solutions Premium Support Partner that brings global reach and scale together with Intel^® certified testing and validation capabilities.

“Lubrizol’s immersion cooled ecosystem solution delivers advantages to today’s data center operators ranging from lower energy costs and higher computing densities to longer server life, all through a more sustainable solution than conventional air cooling,” said Matt Joyce, Vice President, Corporate Business Development for Lubrizol. “Our partnership with Park Place Technologies adds a world-class service, maintenance and monitoring capability to our sustainable offering.”

“Park Place’s industry-leading global service, support, and preventative maintenance capabilities provide the optimal synergy with Lubrizol’s immersion cooled ecosystem solution, delivering a circular economy and sustainability-focused solution aimed at unlocking power densities of the future,” said Chris Adams, President and CEO of Park Place. “Our portfolio of third-party data center hardware maintenance, professional service, infrastructure managed services, network performance monitor and hardware sales, paired with Lubrizol’s novel turn-key solution using CompuZol™ immersion fluid, will deliver substantial value to our customers and end-users, enabling virtually seamless adoption of single-phase immersion cooling technologies with the support of world-class organizations.”

“Scaling innovative technologies such as liquid immersion cooling is critical to maximizing data center power efficiency as well as minimizing data center carbon footprint,” said Jennifer Huffstetler, VP and GM, Data Center Platform Strategy, Mobilization, Sustainability and Services at Intel. “We’re thrilled to see the partnership of Lubrizol and Park Place Technologies to scale the commercial deployment of CompuZol™ based liquid immersion cooling solutions. The combination of Park Place Technologies’ expertise in deploying Intel Xeon^® processor-based solutions along with Lubrizol’s proven, validated, and environmentally friendly CompuZol™ liquids demonstrates the technology is ready for worldwide deployment.”

Lubrizol’s immersion cooled ecosystem solution begins with Lubrizol’s family of patented thermal management CompuZol™ immersion fluids, designed specifically for Data Center, Edge, and Far Edge applications. Through a multi-year collaboration with Intel, and partnerships with other industry leaders in the infrastructure, server design and manufacturing, and immersion tank industries – and now in maintenance and service through Park Place – this ecosystem solution brings together Immersion Cooling with new technology advancement for sustainability, and delivers a turn-key solution for customers looking to unlock higher computing power densities while reducing energy and water consumption and extending server life.

© 2022 David Mazor

Disclosure: David Mazor is a freelance writer focusing on Berkshire Hathaway. The author is long in Berkshire Hathaway, and this article is not a recommendation on whether to buy or sell a stock. The information contained in this article should not be construed as personalized or individualized investment advice. Past performance is no guarantee of future results.

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Lubrizol Life Science Health has completed a major expansion of its U.S. Medical Device Design Center in Corona, California, to enhance collaboration with customers across the full product lifecycle.

This significant investment adds a dedicated development cell with test lab and pilot lines, including an additional 2,600 square feet of ISO-7 cleanroom space. The expansion also includes additional square footage for future development and manufacturing cleanroom space. To promote collaboration, the expanded site now includes areas accessible to customers who are working with the Lubrizol design team.

The U.S. Medical Device Design Center team is led by Eric Mabry, Senior Manager of Device Design, who brings more than 35 years of experience in medical device design and engineering, including balloon development expertise, to the role. The device design team functions as an extension of customer research and development teams by providing innovative designs of catheters and delivery systems in structural heart, electrophysiology, cardiovascular, neurovascular, and peripheral vascular markets.

Strategically located in the heart of Southern California’s medical device industry, the 53,000 square-foot facility is equipped with test laboratories for device testing and benchmarking, prototyping and development, and cleanrooms for volume production.

The U.S. Medical Device Design Center’s capabilities include:

• Precision extrusion
• Braid- and coil-reinforced catheter designs
• Catheter reflow and assembly
• Catheter and delivery system handle design
• Balloon design, bonding, pleating and folding
• Catheter and device performance testing (including burst and leak testing)
• Rapid prototyping
• Laser welding, cutting, and drilling
• Final device packaging

Lubrizol Life Science Health capabilities at the U.S. Medical Device Design Center are complemented by a similar integrated design and development center near Munich, Germany. The full device design team across the U.S. and Europe includes more than 35 engineers and technicians with a combined total of over 425 years of experience and more than 85 patents. There are 110 employees at the U.S. Medical Device Design Center across all phases of design and manufacturing.

© 2022 David Mazor

Disclosure: David Mazor is a freelance writer focusing on Berkshire Hathaway. The author is long in Berkshire Hathaway and BYD, and this article is not a recommendation on whether to buy or sell a stock. The information contained in this article should not be construed as personalized or individualized investment advice. Past performance is no guarantee of future results.

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Lubrizol Life Science – Beauty (LLS Beauty) has created Foresee Lab, a program which combines science, future thinking and consumer and market insights to give brands a clear picture of the future of beauty. This allows clients to anticipate and benefit from new developments while giving their customers what they desire as soon as they want it.

In partnership with LLS Consumer and Market Insights team, Foresee Lab collects key market and consumer insights locally and globally to identify growth opportunities. For example, an online product review analysis tool uses AI to identify millions of consumer reviews across different beauty segments while agile video analysis captures consumer behavior for quick feedback on ideas and concepts.

Finally, Foresee Lab connects these trends and consumer insights with the LLS Beauty portfolio of active and functional ingredients and expert formulation capabilities. The results are new market concepts and product line opportunities for clients, as well as new formulations that enhance performance, deliver esthetic benefits, and provide a superior sensory experience for consumers.

LLS Beauty clients don’t need not worry about the future of the industry. With Foresee Lab, they can make decisions today to shape the future of beauty that they envision.

© 2022 David Mazor

Disclosure: David Mazor is a freelance writer focusing on Berkshire Hathaway. The author is long in Berkshire Hathaway, and this article is not a recommendation on whether to buy or sell a stock. The information contained in this article should not be construed as personalized or individualized investment advice. Past performance is no guarantee of future results.

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Berkshire Hathaway’s The Lubrizol Corporation has signed an investment intention agreement with Songjiang District People’s government, which outlined Lubrizol’s commitment to increasing investment, including setting up an R&D center and further enhancing its capabilities to drive continuous growth in China market.

On July 28, the Shanghai municipal government held a group signing ceremony for foreign investment projects in Shanghai. Lubrizol was invited to participate and signed the investment intention agreement.

As part of its commitment, Lubrizol will invest in the construction of a new “Lubrizol lubricant additive R&D center” in Songjiang, Shanghai. As an important part of Lubrizol’s global R&D network, the Shanghai R&D center will be responsible for research, design and testing of additive solutions for the Chinese transportation market, including fuel vehicles, hybrid vehicles and new energy vehicles, providing customers with reliable solutions that help the world Move Cleaner by extending product life, reducing emissions and reducing environmental impact.

Dong Jian-Wei, vice president of Lubrizol Additives in Asia Pacific, who attended the signing ceremony, said, “China continues to be an important growth region for the transportation industry, and we look forward to advancing this growth through a local R&D and innovation center to support local needs.”

He added: “Under the guidance of China’s ‘2030.2060’ dual carbon goal, many industries, including the automotive industry, are facing increasing demands for more sustainable solutions. We believe that this R&D center close to the local market will strategically improve our core technical capabilities locally, accelerate the implementation of the overall R&D strategy and objectives of the business, and support our customers.”

Since entering the Chinese market, Lubrizol has established production bases, R&D and technical service centers in Zhuhai, Guangdong and Songjiang, Shanghai to provide customers with valuable technical solutions and promote the rapid development of the company’s business in China.

© 2021 David Mazor

Disclosure: David Mazor is a freelance writer focusing on Berkshire Hathaway. The author is long in Berkshire Hathaway, and this article is not a recommendation on whether to buy or sell a stock. The information contained in this article should not be construed as personalized or individualized investment advice. Past performance is no guarantee of future results.

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Berkshire Hathaway’s Lubrizol Advanced Materials, Inc., inventors and the largest manufacturers of CPVC compound worldwide, and Prince Pipes and Fittings Ltd., have signed a definitive agreement of Corzan® CPVC Processor for the manufacturing and sale of Corzan® CPVC Material and Piping solutions in India. With this collaboration, Lubrizol will broaden its product offerings in the Indian industrial piping sector and will strengthen the position of Prince Pipes and Fittings Ltd in the industrial piping systems in India.

Corzan® CPVC will be available across India through Prince Pipes and Fittings Ltd. starting September 2021.

Lubrizol is a pioneer in CPVC piping technology and its Corzan® CPVC has a long history of withstanding high pressures and corrosive chemicals. Corzan® CPVC is known for its reliability, consistency, efficiency, and productivity without disruptions.

It is mainly used for transporting chemicals, industrial water treatment, mineral processing, and oil & gas applications. Corzan® CPVC is recyclable and is used again as an additive in other vinyl compounds in line with Lubrizol’s sustainability goals of Move Cleaner, Create Smarter, Live Better.

Commenting on the collaboration Mr. Nihar Chheda, VP, Prince Pipes and Fittings Limited, said, “We are delighted to associate with Lubrizol once again. Prince Pipes is not about creating products that are different but providing solutions that make a difference. We have driven change in the industry by replacing conventional products, with high-performance user-friendly solutions. The Indian Industrial piping market has huge potential of ~INR. 160 billion. This is today dominated by the conventional MSRL pipes and low adoption of CPVC, which is majorly used only for domestic applications. Whereas globally, Corzan® CPVC pipes are well accepted for Industrial applications. This association strengthens Prince Pipes’ portfolio of existing range of industrial solutions. Prince OneFit with Corzan® CPVC Technology will solve corrosion issues while decreasing the downtime enabling continuous production. This reflects our strong intent to continue to drive high-impact change for higher value creation.”

© 2021 David Mazor

Disclosure: David Mazor is a freelance writer focusing on Berkshire Hathaway. The author is long in Berkshire Hathaway, and this article is not a recommendation on whether to buy or sell the stock. The information contained in this article should not be construed as personalized or individualized investment advice. Past performance is no guarantee of future results.

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Berkshire Hathaway’s Lubrizol Corporation has announced new Electro-Rite Polymer Technology for lithium-ion battery-cell construction to deliver new performance capabilities.

As global demands for energy storage continue to expand, lithium-ion battery systems must evolve. With a commitment to its new Electro-Rite Polymer Technology, Lubrizol is dedicated to innovating advanced binder and dispersant technologies for anode, cathode and separator components to improve energy density and extend battery life.

The technology includes polymers designed to improve performance of electrodes, separators, and electrolyte components. Specifically, Electro-Rite polymer technology can help enhance binder slurry formulation, aid in the formulation of advanced anodes and separators, and deliver new primer capabilities.

The company’s Electro-Rite® Technologies for Batteries are advanced material solutions for inside the battery, designed to improve performance of electrodes, separators, and electrolyte components. The Electro-Rite portfolio includes unique binder materials for anodes and separators for improving cell performance. The portfolio also includes dispersants and rheology modifiers that enhance dispersion, viscosity, flow properties and suspension of carbon, graphite, silicon, silicon oxide and ceramic active materials in aqueous slurries for optimal coating applications.

© 2021 David Mazor

Disclosure: David Mazor is a freelance writer focusing on Berkshire Hathaway. The author is long in Berkshire Hathaway, and this article is not a recommendation on whether to buy or sell the stock. The information contained in this article should not be construed as personalized or individualized investment advice. Past performance is no guarantee of future results.

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Berkshire Hathaway’s Lubrizol Corporation has suffered a catastrophic fire at its Chemtool plant in Rockton. Illinois. The fire has multiple area fire departments battling the blaze, which was first called in around 7:00am. One firefighter has reportedly been injured.

The fire has forced the mandatory evacuation of everyone within a one-mile area of the plant, and people took shelter in the Roscoe Middle School.

“At approximately 7 a.m. today, local emergency personnel responded to a fire at the Lubrizol Corporation’s Chemtool Facility in Rockton, Ill. We have confirmed all on site are safe and accounted for. Our concern right now is for the safety of all our employees and the surrounding community. As a precaution, authorities have evacuated residents in a one-mile radius of the site. We do not yet know what caused this incident, but we will be working with local authorities and with our own risk management team to determine what happened and identify any corrective actions. We will share more details as they are known. We are grateful to our employees, first responders and safety forces responding to this incident,” Alicia Gauer, Senior Director, Global Communications for the Lubrizol Corporation said.

© 2021 David Mazor

Disclosure: David Mazor is a freelance writer focusing on Berkshire Hathaway. The author is long in Berkshire Hathaway, and this article is not a recommendation on whether to buy or sell the stock. The information contained in this article should not be construed as personalized or individualized investment advice. Past performance is no guarantee of future results.